Individuals vary greatly in their mental health and these differences may play a critical role in stress resistance, risk reduction and illness recovery. Here we ask how these differences may be related to normal variation in personality and genotype. One hundred healthy college students completed measures of mental health (Mental Health Continuum‐Short Form [MHC‐SF]), personality (NEO Five Factor Inventory) and adverse childhood experiences. Participants also provided saliva samples, genotyped for both the serotonin transporter (5‐HTTLPR) and the brain‐derived neurotrophic factor (BDNF), each assayed for naturally occurring polymorphisms, 5‐HTTLPR (short/long) and BDNF (valine/methionine). Mental health correlated strongly with the NEO triad of conscientiousness‐extraversion‐neuroticism, with largest contributions to MHC‐SF scores for conscientiousness, followed by extraversion and then neuroticism. The personality trait interaction of extraversion × conscientiousness uniquely accounted for approximately 44.22% 44.62% of the variance in MHC‐SF scores. Polygenic comparisons showed a significant gene × gene interaction, with highest mental health for 5‐HTTLPR‐S, Met carriers. Together these results provided support for distinct yet interacting roles of personality and genetics in the phenotypical expression of mental health.

中文翻译：

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寻求积极的心理健康：人格特征和遗传多态性

个体的心理健康差异很大，这些差异可能在抗压、降低风险和疾病康复方面发挥关键作用。在这里，我们询问这些差异如何与人格和基因型的正常变异相关。100 名健康大学生完成了心理健康（心理健康连续统简表 [MHC-SF]）、人格（NEO 五因素量表）和不良童年经历的测量。参与者还提供了唾液样本，对血清素转运蛋白 (5-HTTLPR) 和脑源性神经营养因子 (BDNF) 进行基因分型，每种都检测了天然发生的多态性、5-HTTLPR（短/长）和 BDNF（缬氨酸/蛋氨酸） . 心理健康与新天体的责任心-外向-神经质三元组密切相关，对责任心的 MHC-SF 得分贡献最大，其次是外向性，然后是神经质。外向性 × 尽责性的人格特质相互作用唯一地解释了 MHC-SF 得分方差的大约 44.22% 和 44.62%。多基因比较显示出显着的基因×基因相互作用，5-HTTLPR-S、Met 携带者的心理健康状况最高。这些结果共同为人格和遗传学在心理健康表型表达中的不同但相互作用的作用提供了支持。5-HTTLPR-S、Met 携带者的心理健康水平最高。这些结果共同为人格和遗传学在心理健康表型表达中的不同但相互作用的作用提供了支持。5-HTTLPR-S、Met 携带者的心理健康水平最高。这些结果共同为人格和遗传学在心理健康表型表达中的不同但相互作用的作用提供了支持。