当前位置:
X-MOL 学术
›
J. Biophotonics
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Miniaturized all fiber probe for optical coherence tomography and pH detection of biological tissue
Journal of Biophotonics ( IF 2.8 ) Pub Date : 2020-10-13 , DOI: 10.1002/jbio.202000239 Minghui Chen 1 , Jianping Wang 1 , Weijie Tan 1 , Yuanyuan Feng 1 , Gang Zheng 1
Journal of Biophotonics ( IF 2.8 ) Pub Date : 2020-10-13 , DOI: 10.1002/jbio.202000239 Minghui Chen 1 , Jianping Wang 1 , Weijie Tan 1 , Yuanyuan Feng 1 , Gang Zheng 1
Affiliation
We present a novel all‐fiber probe with 710‐μm outside diameter for combined optical coherence tomography and pH detection. In cancer surgery, a significant challenge is how to completely remove the malignant tumor without cutting too much normal tissue. The difference between cancer tissue and normal tissue not only lies in morphology and structure but also in tissue pH, where malignant tissue has a lower pH. This dual‐modality probe combined optical coherence tomography and pH detection of biological tissue, is expected to determine whether the tissue is cancerous quickly and accurately. The probe utilizes a typical three‐segment structure (double‐clad fiber ‐ no‐core fiber ‐ graded‐index fiber). We obtained a lateral resolution of ~10.6 μm, a working distance of ~506 μm and a pH measurement accuracy of 0.01 pH unit for the probe. The performance of the all‐fiber probe was verified through an ex vivo experiment using the porcine brain specimen.
中文翻译:
微型全光纤探头,用于光学相干断层扫描和生物组织的pH检测
我们提出了一种外径为710μm的新型全光纤探头,用于光学相干断层扫描和pH检测。在癌症手术中,一个重大挑战是如何在不切除过多正常组织的情况下完全清除恶性肿瘤。癌组织与正常组织之间的差异不仅在于形态和结构,还在于组织pH值,其中恶性组织的pH值较低。这种双模态探针结合了光学相干断层扫描和生物组织的pH检测,有望确定组织是否快速,准确地癌变。该探头采用典型的三段式结构(双包层光纤无芯光纤渐变折射率光纤)。我们获得的横向分辨率为〜10.6μm,工作距离为〜506μm,探针的pH测量精度为0.01 pH单位。
更新日期:2020-10-13
中文翻译:
微型全光纤探头,用于光学相干断层扫描和生物组织的pH检测
我们提出了一种外径为710μm的新型全光纤探头,用于光学相干断层扫描和pH检测。在癌症手术中,一个重大挑战是如何在不切除过多正常组织的情况下完全清除恶性肿瘤。癌组织与正常组织之间的差异不仅在于形态和结构,还在于组织pH值,其中恶性组织的pH值较低。这种双模态探针结合了光学相干断层扫描和生物组织的pH检测,有望确定组织是否快速,准确地癌变。该探头采用典型的三段式结构(双包层光纤无芯光纤渐变折射率光纤)。我们获得的横向分辨率为〜10.6μm,工作距离为〜506μm,探针的pH测量精度为0.01 pH单位。