The first months of life represent a crucial time period for an infant. Alongside establishing the early microbiome, the mucosal immunological homeostasis is being developed. Both processes may be perturbed in prematurely born infants. The glycoprotein SALSA plays a role in mucosal inflammation and microbial clearance. It is one of the most abundant molecules on the intestinal mucosal surfaces in early life. SALSA binds to many types of microbes and host defence molecules like IgA, C1q and collectin molecules. We here describe the development in faecal SALSA levels during the first three months of life. During these 90 days, the median SALSA level in full‐term babies decreased from 1100 μg/mL (range 49‐17 000 μg/mL) to 450 μg/mL (range 33‐1000 μg/mL). Lower levels of SALSA were observed in prematurely born infants in the same time period. Our novel observation thus indicates an impact of prematurity on an important component of the infant intestinal immune system. Changes in SALSA in early life may have an effect on the early establishment of the human microbiome.

中文翻译：

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早产儿的肠道SALSA / dmbt1水平降低

生命的头几个月代表婴儿的关键时期。除了建立早期的微生物组，粘膜免疫稳态也正在发展中。早产儿都可能对这两个过程感到不安。糖蛋白SALSA在粘膜炎症和微生物清除中起作用。它是生命早期肠道粘膜表面上最丰富的分子之一。SALSA与许多类型的微生物和宿主防御分子（例如IgA，C1q和collectin分子）结合。我们在此描述生命头三个月中粪便SALSA水平的发展。在这90天内，足月婴儿的SALSA中位数从1100μg/ mL（范围为49-17 000μg/ mL）降低到450μg/ mL（范围为33-1000μg/ mL）。在同一时期，早产儿的SALSA水平较低。因此，我们的新发现表明，早产对婴儿肠道免疫系统的重要组成部分有影响。生命早期SALSA的变化可能会对人类微生物组的早期建立产生影响。