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TLR10: Insights, controversies and potential utility as a therapeutic target
Scandinavian Journal of Immunology ( IF 3.7 ) Pub Date : 2020-10-12 , DOI: 10.1111/sji.12988
Si‐Biao Su 1 , Lin Tao 1 , Ze‐Ping Deng 1 , Wen Chen 2 , Shan‐Yu Qin 1 , Hai‐Xing Jiang 1
Affiliation  

The Toll‐like receptor (TLR) family acts as a bridge connecting innate and acquired immunity. TLR10 remains one of the least understood members of this family. Some studies have examined TLR10 ligands, dimerization of TLR10 with other TLRs, and downstream signalling pathways and functions, but they have often arrived at conflicting conclusions. TLR10 can induce the production of proinflammatory cytokines by forming homodimers with itself or heterodimers with TLR1 or other TLRs, but it can also inhibit proinflammatory responses when co‐expressed with TLR2 or potentially other TLRs. Mutations in the Toll/Interleukin 1 receptor (TIR) domain of TLR10 alter its signalling activity. Polymorphisms in the TLR10 gene can change the balance between pro‐ and anti‐inflammatory responses and hence modulate the susceptibility to infection and autoimmune diseases. Understanding the full range of TLR10 ligands and functions may allow the receptor to be exploited as a therapeutic target in inflammation‐ or immune‐related diseases. Here, we summarize recent findings on the pro‐ and anti‐inflammatory roles of TLR10 and the molecular pathways in which it is implicated. Our goal is to pave the way for future studies of the only orphan TLR thought to have strong potential as a target in the treatment of inflammation‐related diseases.

中文翻译:

TLR10:见解,争议和作为治疗靶标的潜在效用

Toll样受体(TLR)家族充当连接先天和后天免疫力的桥梁。TLR10仍然是这个家族中鲜为人知的成员之一。一些研究检查了TLR10配体,TLR10与其他TLR的二聚作用以及下游信号传导途径和功能,但它们经常得出相互矛盾的结论。TLR10可以通过自身形成同二聚体或与TLR1或其他TLR形成异二聚体来诱导促炎性细胞因子的产生,但是当与TLR2或潜在地与其他TLR共同表达时,它也可以抑制促炎反应。TLR10的Toll /白介素1受体(TIR)域中的突变会改变其信号传导活性。TLR10基因的多态性可以改变促炎和抗炎反应之间的平衡,从而调节对感染和自身免疫性疾病的敏感性。了解TLR10配体和功能的全部范围,可以使该受体被用作炎症或免疫相关疾病的治疗靶标。在这里,我们总结了有关TLR10的促炎和抗炎作用及其涉及的分子途径的最新发现。我们的目标是为将来唯一被认为具有强大潜力作为治疗炎症相关疾病目标的孤儿TLR铺平道路。我们总结了有关TLR10的促炎和抗炎作用以及与之相关的分子途径的最新发现。我们的目标是为将来唯一被认为具有强大潜力作为治疗炎症相关疾病目标的孤儿TLR铺平道路。我们总结了有关TLR10的促炎和抗炎作用以及与之相关的分子途径的最新发现。我们的目标是为唯一的孤儿TLR的未来研究铺平道路,后者被认为具有很强的潜力作为治疗炎症相关疾病的靶标。
更新日期:2020-10-12
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