Pterocarpus mildbraedii (PME) is a green leafy vegetable from the Papilionaceae family. This study evaluated the anti‐inflammatory activity of PME in Wistar rats exposed to experimental hepatotoxicity using propanil (PRP), a post‐emergent herbicide. Animals were grouped as control, PRP, PME, and PME + PRP. After 7 days, the levels of stress‐activated protein kinases/c‐Jun N‐terminal kinase (SAPK/JNK), p38 mitogen‐activated protein kinase (p38 MAPK), and signal transducer and activator of transcription (STAT‐3) were measured in rat liver. Furthermore, myeloperoxidase (MPO) and nitric oxide (NO) levels, as well as protein expressions of nuclear factor‐κB (NF‐κB p65), inducible nitric oxide synthase (iNOS), and cyclo‐oxygenase‐2 (COX‐2) were determined. Compared with PRP‐treated rats, PME significantly reduced the hepatic MPO and NO levels. PME also diminished NFκB, iNOS, and COX‐2 protein expressions in PRP‐treated rats. This study showed that Pterocarpus mildbraedii leaves produce active principles with relevant anti‐inflammatory potential.

中文翻译：

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紫檀（Harms）提取物通过抑制Wistar大鼠的炎症应激反应来解决丙烷诱发的肝损伤

罗汉松（PME）是Papilionaceae家族的绿叶蔬菜。这项研究使用出苗后的除草剂丙烷（PRP）评估了暴露于实验性肝毒性的Wistar大鼠中PME的抗炎活性。将动物分为对照组，PRP，PME和PME + PRP。7天后，应激激活蛋白激酶/ c-Jun N末端激酶（SAPK / JNK），p38丝裂原激活蛋白激酶（p38 MAPK）以及信号转导和转录激活因子（STAT-3）的水平在大鼠肝脏中测量。此外，髓过氧化物酶（MPO）和一氧化氮（NO）的水平，以及核因子κB（NF-κBp65），诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）的蛋白表达被确定。与PRP处理的大鼠相比，PME显着降低了肝MPO和NO水平。PME还减少了NFκB，iNOS，PRP处理的大鼠中的COX和COX-2蛋白表达。这项研究表明紫罗兰叶产生具有相关抗炎潜力的有效成分。