Milk thistle cold press oil (MTO) is an herbal remedy derived from Silybum marianum which contains a low level of silymarin and mixture of polyphenols and flavonoids. The effect of MTO on the cardiovascular and metabolic complications of obesity was studied in mice that were fed a high‐fat diet (HFD) for 20 weeks and treated with MTO for the final 8 weeks of the diet. MTO treatment attenuated HFD‐induced obesity, fasting hyperglycemia, hypertension, and induced markers of mitochondrial fusion and browning of white adipose. Markers of inflammation were also attenuated in both adipose and the liver of MTO‐treated mice. In addition, MTO resulted in the improvement of liver fibrosis. These results demonstrate that MTO has beneficial actions to attenuate dietary obesity‐induced weight gain, hyperglycemia, hypertension, inflammation, and suggest that MTO supplementation may prove beneficial to patients exhibiting symptoms of metabolic syndrome.

中文翻译：

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乳蓟种子冷榨油可减轻饮食性肥胖小鼠模型中代谢综合征的标志

乳蓟冷榨油（MTO）是源自水飞蓟的草药其中含有少量的水飞蓟素以及多酚和类黄酮的混合物。在喂养高脂饮食（HFD）20周并在饮食的最后8周接受MTO治疗的小鼠中，研究了MTO对肥胖的心血管和代谢并发症的影响。MTO治疗可减轻HFD引起的肥胖，禁食高血糖，高血压以及诱导的线粒体融合标志物和白色脂肪褐变。在接受MTO治疗的小鼠的脂肪和肝脏中，炎症标记也都减弱了。此外，MTO改善了肝纤维化。这些结果表明，MTO具有减轻饮食性肥胖引起的体重增加，高血糖，高血压，炎症，