Objective

Local activation of B cells and antibody production are important for protective and pathogenic immune responses. Furthermore, there is evidence that local activation of B cells and antibody production are important for pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) and a severe subset of CRSwNP, aspirin-exacerbated respiratory disease (AERD). This review summarizes these findings and the potential role of B cells and antibodies in disease pathogenesis.

Data Sources

Published literature from PubMed searches.

Study Selections

Studies relevant to B cell development and the roles of B cells and antibodies in the pathogenesis of CRSwNP and AERD.

Results

Formation of tertiary lymphoid structures plays a key role in the local activation of B cells and antibody production. This process is important for fighting infections, but it also contributes to autoimmune disease. Furthermore, there is evidence to support a role for local B cell activation and antibody production in a variety of allergic diseases. Nasal polyp tissues from patients with CRSwNP and AERD have elevated levels of activated B cell subsets and locally produced antibodies. These locally produced antibodies may contribute to disease pathogenesis in a variety of ways, including activation of innate effector cells, whereas locally activated B cells may contribute to pathogenesis through the activation of T cells.

Conclusion

More studies are needed to determine the role of B cells and antibodies in driving disease in these patients. However, targeting the processes that drive local B cell activation and antibody production may provide new therapeutic approaches and could help to reduce chronic inflammation.

中文翻译：

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鼻组织中局部免疫球蛋白的产生

客观的

B 细胞的局部激活和抗体产生对于保护性和致病性免疫反应很重要。此外，有证据表明，B 细胞的局部活化和抗体产生对于慢性鼻窦炎伴鼻息肉 (CRSwNP) 和 CRSwNP 的严重亚型，即阿司匹林加重的呼吸道疾病 (AERD) 的发病机制很重要。本综述总结了这些发现以及 B 细胞和抗体在疾病发病机制中的潜在作用。

数据源

来自 PubMed 搜索的已发表文献。

研究选择

与 B 细胞发育相关的研究以及 B 细胞和抗体在 CRSwNP 和 AERD 发病机制中的作用。

结果

三级淋巴结构的形成在 B 细胞的局部活化和抗体产生中起关键作用。这个过程对于抵抗感染很重要，但它也会导致自身免疫性疾病。此外，有证据支持局部 B 细胞活化和抗体产生在多种过敏性疾病中的作用。CRSwNP 和 AERD 患者的鼻息肉组织具有升高的活化 B 细胞亚群水平和局部产生的抗体。这些局部产生的抗体可能以多种方式促成疾病发病机制，包括激活先天效应细胞，而局部激活的 B 细胞可能通过激活 T 细胞参与发病机制。

结论

需要更多的研究来确定 B 细胞和抗体在这些患者中驱动疾病的作用。然而，针对驱动局部 B 细胞活化和抗体产生的过程可能会提供新的治疗方法，并有助于减少慢性炎症。