Fourteen undescribed diterpenoids caryopterisoids D - Q, three undescribed iridoid glucoside derivatives caryopterisides F - H, and 8 known diterpenoids were isolated from the 95% aqueous ethanolic extract of Caryopteris glutinosa. Their structures were elucidated on the basis of spectroscopic data analysis and chemical derivation studies. The structure and absolute configuration of caryopterisoid D were confirmed by X-ray crystallographic analysis. Caryopterisoids K and R, royleanone, 6α-hydroxydemethylcryptojaponol, and teuvincenone E were shown to reduce the biosynthesis of estrogen E2 with IC50 values from 0.25 to 3.06 μM in cell-based estrogen biosynthesis assays system.

中文翻译：

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来自 Caryopteris glutinosa 的二萜类 caryopterisoids D - Q 和环烯醚萜苷衍生物 caryopterisides F - H

从 Caryopteris glutinosa 的 95% 含水乙醇提取物中分离出 14 种未描述的二萜类 Caryopterisoids D-Q、三种未描述的环烯醚萜苷衍生物 Caryopterisides F-H 和 8 种已知的二萜。在光谱数据分析和化学推导研究的基础上阐明了它们的结构。通过 X 射线晶体学分析证实了核翅目 D 的结构和绝对构型。在基于细胞的雌激素生物合成分析系统中，Caryopterisoids K 和 R、royleanone、6α-羟基脱甲基隐花酮和 teuvincenone E 被证明可以减少雌激素 E2 的生物合成，IC50 值从 0.25 到 3.06 μM。