Background and purpose

The main purpose of this retrospective study was to evaluate inter-software variability in patients affected of a high-grade glioma for the post-processing of dynamic susceptibility contrast (DSC¹) perfusion imaging in MRI.²

Materials and methods

The included patients were either anaplastic astrocytoma (WHO³ grade III) or glioblastoma (WHO grade IV) located in the cerebral parenchyma. The postprocessing of 54 MRI-DSC imaging from 46 patients using both Intellispace.. (Philips) and Olea.. (Olea Medical) software was performed. The hemodynamic parameter studied was the normalised relative cerebral blood volume corrected for the T1 leakage effect (nrCBVc⁴). The inter-operator variabilities were also evaluated.

Results

Regarding inter-software reproducibility, Cohen...s Kappa from therapeutic follow-up obtained were 0.61, close to the recommended limit (0.60). Subgroups were created to complete the analysis and to evaluate the partial volume effect. Even if necrosis or vascular structures from regions of interest (ROI⁵) were avoided, results did not improve. ROI of a minimum area of 250...mm² yielded a Cohen...s Kappa of 0.65. The inter-operator reproducibility on Intellispace and Olea were 0.90 and 0.73 respectively, which is satisfactory.

Conclusion

The reproducibility between Intellispace and Olea was below recommended threshold in a clinical context. This discrepancy can be explained by the partial volume effect and the models used. ROI with an area of at least 250...mm² improves this reproducibility and becomes acceptable.

中文翻译：

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在受高级别胶质瘤影响的患者中比较动态磁敏性对比灌注后处理与不同的临床可用软件

背景和目的

这项回顾性研究的主要目的是评估受高级神经胶质瘤影响的患者的软件间变异性，以便在 MRI 中进行动态磁化率对比 (DSC ¹ ) 灌注成像的后处理。²

材料和方法

纳入的患者为位于脑实质的间变性星形细胞瘤（WHO ^{3 III 级）或胶质母细胞瘤（WHO IV 级）。}使用 Intellispace.. (Philips) 和 Olea.. (Olea Medical) 软件对来自 46 名患者的 54 次 MRI-DSC 成像进行了后处理。^{研究的血流动力学参数是针对 T1 泄漏效应 (nrCBVc 4} )校正的标准化相对脑血容量。还评估了运营商间的可变性。

结果

关于软件间的可重复性，从治疗随访中获得的 Cohen...s Kappa 为 0.61，接近推荐限值 (0.60)。创建亚组以完成分析并评估部分体积效应。即使避免了来自感兴趣区域 (ROI ⁵ ) 的坏死或血管结构，结果也没有改善。最小面积为 250...mm ²的 ROI产生了 0.65 的 Cohen...s Kappa。Intellispace 和 Olea 上的操作者间重现性分别为 0.90 和 0.73，令人满意。

结论

Intellispace 和 Olea 之间的可重复性低于临床环境中的推荐阈值。这种差异可以通过部分体积效应和使用的模型来解释。面积至少为 250...mm ²的 ROI提高了这种再现性并变得可以接受。