In this work we address the issue of validating the monodomain equation used in combination with the Bueno-Orovio ionic model for the prediction of the activation times in cardiac electro-physiology of the left ventricle. To this aim, we consider four patients who suffered from Left Bundle Branch Block (LBBB). We use activation maps performed at the septum as input data for the model and maps at the epicardial veins for the validation. In particular, a first set (half) of the latter are used to estimate the conductivities of the patient and a second set (the remaining half) to compute the errors of the numerical simulations. We find an excellent agreement between measures and numerical results. Our validated computational tool could be used to accurately predict activation times at the epicardial veins with a short mapping, i.e. by using only a part (the most proximal) of the standard acquisition points, thus reducing the invasive procedure and exposure to radiation.

在这项工作中，我们解决了验证与Bueno-Orovio离子模型结合使用的单域方程，以预测左心室心脏电生理中激活时间的问题。为此，我们考虑了四名患有左束支传导阻滞（LBBB）的患者。我们使用在隔垫处执行的激活图作为模型的输入数据，并在心外膜静脉处使用图进行验证。特别是，后者的第一组（一半）用于估计患者的电导率，第二组（其余一半）用于计算数值模拟的误差。我们发现测度和数值结果之间有很好的一致性。我们经过验证的计算工具可用于通过较短的映射准确预测心外膜静脉的激活时间，即