Hydrogen peroxide (H₂O₂) is a high-value green chemical oxidant widely used for industrial bleaching, chemical synthesis, and disinfection. Industrially, H₂O₂ is produced through the energy-intensive anthraquinone process and distributed to the point of use. There is a growing interest in electrochemically producing H₂O₂ onsite to mitigate transportation cost and safety concerns and leveraging renewable electricity. Most research has been dedicated to the two-electron oxygen reduction to produce H₂O₂. For the past decade, growing attention has been paid to the two-electron water oxidation reaction (2e-WOR) to produce H₂O₂. This review focuses on the research progress on 2e-WOR, including basic principles, catalyst development, and H₂O₂ detection. Computational approaches to study candidate materials for 2e-WOR are detailed, and various experimental reports on catalysts are summarized. Ulterior electrochemical factors that impact H₂O₂ production are discussed, along with device-level design. Finally, a holistic perspective on water oxidation reaction is offered, and open questions for future work are presented.

过氧化氢（H ₂ O ₂）是一种高价值的绿色化学氧化剂，广泛用于工业漂白，化学合成和消毒。在工业上，H ₂ O ₂通过高能耗的蒽醌工艺生产并分配到使用点。人们对在现场电化学生产H ₂ O ₂以减轻运输成本和安全问题以及利用可再生电力的兴趣日益增长。大多数研究致力于将二电子氧还原以产生H ₂ O ₂。在过去的十年中，越来越多的注意力转移到两电子水氧化反应（2e-WOR）来生产H₂ O ₂。本文综述了2e-WOR的研究进展，包括基本原理，催化剂的开发和H ₂ O _2的检测。详细介绍了研究2e-WOR候选材料的计算方法，并总结了有关催化剂的各种实验报告。讨论了影响H ₂ O ₂产生的有害的电化学因素，以及器件级设计。最后，提供了关于水氧化反应的整体观点，并提出了未来工作的未解决问题。