In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.

在许多方面，癌细胞不同于健康细胞。许多基于战术的纳米药物递送系统都是基于癌症和健康细胞之间的差异。当前，基于纳米技术的递送系统是将基于DNA的产品递送至癌细胞的最有前途的工具。这篇综述旨在强调用于siRNA递送至癌细胞的脂质和聚合物纳米载体的最新发展。它还提供了有关siRNA发育及其作用机制的必要信息。总的来说，这篇综述为我们提供了基于脂质和聚合物的药物递送系统的清晰图片，该系统将来可能构成将基础siRNA生物学转化为基于siRNA的癌症治疗的基础。