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White matter characteristics between amygdala and prefrontal cortex underlie depressive tendency in end stage renal disease patients before the dialysis initiation
Brain Imaging and Behavior ( IF 3.2 ) Pub Date : 2020-10-13 , DOI: 10.1007/s11682-020-00376-6
Junya Mu 1, 2 , Liang Ma 1, 2 , Dun Ding 3 , Xueying Ma 4 , Peng Li 5, 6 , Ruixiao Li 1, 2 , Ming Zhang 5 , Jixin Liu 1, 2
Affiliation  

Depression is one of the common incidental symptoms in end-stage renal disease (ESRD) patients, empirically overlooked. Reproducible results observed that altered interregional white matter (WM) connections between depression-related brain regions (thalamus, amygdala, and prefrontal cortex (PFC)) in the human brain were closely associated with depression. Whether the depressive tendency of ESRD patients is also association with the WM connections is remains unknown. To address this problem, 56 ESRD patients before dialysis initiation and 56 healthy controls (HCs) were scanned with diffusion tensor imaging. According to the diagnostic and statistical manual of mental disorders, ESRD patients were separated into with and without depressive tendency groups. Twenty-five essential metabolites were tested in ESRD. The tractography atlas-based analysis and multiple regression analysis were implemented to gain features which could map the depressive tendency variability across ESRD. For metabolites, the levels of thrombocytes and calcium have significant differences between with and without depressive tendency groups. For WM microstructure, depressive tendency ESRD patients had abnormal WM diffusion properties along the fiber tracts of the amygdala-PFC. Compared with the features which were extracted from the group-difference of WM or metabolites, only WM features combinations (1000 bootstrap samples; 5000 permutation tests) along the fiber tract of the amygdala-PFC was a significant predictor of either with or without depressive tendency. Our findings suggested that the advanced neuroprotection may be planned before dialysis initiation, and the WM characteristics of amygdala-PFC may be a potential neuromarkers for the early diagnosis of depressive tendency in ESRD patients before dialysis initiation.



中文翻译:

透析开始前终末期肾病患者的杏仁核和前额叶皮层之间的白质特征是抑郁倾向的基础

抑郁症是终末期肾病 (ESRD) 患者常见的附带症状之一,但在经验上被忽视。可重复的结果观察到,人脑中与抑郁相关的大脑区域(丘脑、杏仁核和前额叶皮层 (PFC))之间区域间白质 (WM) 连接的改变与抑郁症密切相关。ESRD 患者的抑郁倾向是否也与 WM 连接有关尚不清楚。为了解决这个问题,在透析开始前对 56 名 ESRD 患者和 56 名健康对照 (HC) 进行了扩散张量成像扫描。根据精神障碍诊断与统计手册,将终末期肾病患者分为有抑郁倾向组和无抑郁倾向组。在 ESRD 中测试了 25 种必需代谢物。实施了基于纤维束图谱的分析和多元回归分析,以获得可以映射 ESRD 抑郁倾向变异性的特征。对于代谢物,有抑郁倾向组和无抑郁倾向组的血小板和钙水平有显着差异。对于 WM 微观结构,抑郁倾向的 ESRD 患者沿杏仁核-PFC 的纤维束具有异常的 WM 扩散特性。与从 WM 或代谢物的组差异中提取的特征相比,只有沿着杏仁核-PFC 纤维束的 WM 特征组合(1000 个引导样本;5000 个排列测试)是有或没有抑郁倾向的重要预测因子. 我们的研究结果表明,可以在透析开始之前计划高级神经保护,

更新日期:2020-10-13
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