The model and algorithm of intensity-modulated radiotherapy (IMRT) are updated increasingly quickly, but the hardware upgrade of primary hospitals often lags behind. The new generation of intelligent precise radiotherapy platforms provides users with intelligent medical consortium services using big data, artificial intelligence and industrial Internet of Things technology. This technology can ensure that under the real-time guidance of a professional medical consortium, primary hospitals can realize rapid large-scale reverse planning design and can more accurately consider many factors of postprocessing. Although large-scale healthcare systems, such as volumetric-modulated arc therapy and other accurate radiotherapy technologies, have developed rapidly, the development of step-and-shoot-mode IMRT technology is still very important for developing countries. For software, in addition to the conformity of the dose distribution, the modulation speed, convenience and stability of the later dose delivery should also be considered in inverse planning. Therefore, this paper analyzes the main problems in conventional IMRT inverse planning, including the smoothing of the fluence map, the selection of the gantry angle and the dose leakage of tongue–groove effects. To address these issues, a novel Intelligent IoT-based large-scale inverse planning strategy with the key factors of the postmodulation is developed, and a detailed flow chart is also provided. The scheme consists of two steps. The first step is to obtain a relatively optimal combination of gantry angles by considering the dose distribution requirements and constraints and the modulation requirements and constraints. The second step is to optimize the intensity map, to smooth the map based on prior knowledge according to the determined angles, and to obtain the final modulation scheme according to the relevant objectives and constraints of the map decomposition (leaf sequencing). In an experiment, we calculate and validate the clinical head and neck case. Because of the special gantry angle selection, the angle combination is optimized from the initial equivalent distribution to adapt to the target area and protect the nontarget area. The value of the objective function varies greatly after the optimization, especially in the target area, and the target value decreases by approximately 10%. On this basis, we smooth the fluence map by a partial differential equation with prior knowledge and a minimization of the total number of monitor units. It is also shown from the objective function value that the target value is essentially unchanged for the target area, while for the nontarget area, the value decreases by 16%, which is very impressive.