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MIXED-LIGAND COORDINATION POLYMERS: STRUCTURAL DIVERSITY AND PROTECTIVE EFFECT ON CARDIAC ARREST INDUCED BY ANESTHESIA VIA INDUCING Sirt1 PATHWAY
Journal of Structural Chemistry ( IF 0.8 ) Pub Date : 2020-09-01 , DOI: 10.1134/s0022476620090127
Q. -S. Xiao , G. -Z. Ren , J. -J. Li , H. Yin , H. Yu , G. Liu

A reaction of the N-donor ligand 1,3-di(1H-imidazol-1-yl)benzene (dimb) with Co(NO3)2·6H2O and the V-shaped carboxylate ligand biphenyl-3,4′,5-tricarboxylic acid (H3bpt) under hydro- or solvothermal conditions yields two new Co(II)-based coordination polymers with the chemical formulas {Co3(dimb)2(bpt)2(H2O)4]}n (1) and [Co2(dimb)2(Hbpt)2]·H2O (2). Furthermore, the treatment effect of compounds 1 and 2 against cardiac arrest induced by anesthesia is evaluated. Firstly, ELISA is used to detect the content of cardiac troponin T and B brain natriuretic peptide after treatment with the compounds. Moreover, RT-PCR is conducted and the relative expression level of Sirt1 in the rat myocardial tissue is measured.

中文翻译:

混合配体协调聚合物:结构多样性和对通过诱导 Sirt1 通路麻醉诱导的心脏骤停的保护作用

N-供体配体 1,3-二(1H-咪唑-1-基)苯 (dimb) 与 Co(NO3)2·6H2O 和 V 型羧酸盐配体 biphenyl-3,4',5- 的反应三羧酸 (H3bpt) 在水热或溶剂热条件下产生两种新的基于 Co(II) 的配位聚合物,其化学式为 {Co3(dimb)2(bpt)2(H2O)4]}n (1) 和 [Co2( dimb)2(Hbpt)2]·H2O (2)。此外,评价了化合物1和2对麻醉诱导的心脏骤停的治疗效果。首先采用ELISA法检测化合物处理后心肌肌钙蛋白T和B脑钠肽的含量。此外,进行RT-PCR并测量大鼠心肌组织中Sirt1的相对表达水平。
更新日期:2020-09-01
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