Important insights into human health can be obtained through the non-invasive collection and detailed analysis of sweat, a biofluid that contains a wide range of essential biomarkers. Skin-interfaced microfluidic platforms, characterized by soft materials and thin geometries, offer a collection of capabilities for in situ capture, storage, and analysis of sweat and its constituents. In ambulatory uses cases, the ability to provide real-time feedback on sweat loss, rate and content, without visual inspection of the device, can be important. This paper introduces a low-profile skin-interfaced system that couples disposable microfluidic sampling devices with reusable ‘stick-on’ electrodes and wireless readout electronics that remain isolated from the sweat. An ultra-thin capping layer on the microfluidic platform permits high-sensitivity, contactless capacitive measurements of both sweat loss and sweat conductivity. This architecture avoids the potential for corrosion of the sensing components and eliminates the need for cleaning/sterilizing the electronics, thereby resulting in a cost-effective platform that is simple to use. Optimized electrode designs follow from a combination of extensive benchtop testing, analytical calculations and FEA simulations for two sensing configurations: (1) sweat rate and loss, and (2) sweat conductivity, which contains information about electrolyte content. Both configurations couple to a flexible, wireless electronics platform that digitizes and transmits information to Bluetooth-enabled devices. On-body field testing during physical exercise validates the performance of the system in scenarios of practical relevance to human health and performance.

中文翻译：

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具有模块化和可重复使用电子器件的皮肤接口软微流体系统，用于原位电容式传感汗液流失、速率和电导率

通过对汗液的非侵入性收集和详细分析，可以获得对人类健康的重要见解，汗液是一种含有多种重要生物标志物的生物流体。皮肤界面微流体平台的特点是柔软的材料和薄的几何形状，提供了一系列原位捕获、存储和分析汗液及其成分的功能。在流动使用情况下，无需目视检查设备即可提供有关出汗量、速率和内容的实时反馈的能力可能很重要。本文介绍了一种低调的皮肤接口系统，该系统将一次性微流体采样装置与可重复使用的“粘贴”电极和与汗液隔离的无线读出电子设备结合起来。微流体平台上的超薄覆盖层可以对汗液流失和汗液电导率进行高灵敏度、非接触式电容测量。这种架构避免了传感组件腐蚀的可能性，并且无需对电子设备进行清洁/消毒，从而形成一个易于使用、经济高效的平台。优化的电极设计结合了两种传感配置的广泛台式测试、分析计算和 FEA 模拟：(1) 出汗率和损失，以及 (2) 汗液电导率，其中包含有关电解质含量的信息。这两种配置都与灵活的无线电子平台相连，该平台可将信息数字化并传输到支持蓝牙的设备。体育锻炼期间的现场测试可验证系统在与人类健康和表现实际相关的场景中的性能。