Background: Parkinson’s disease is a common neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta.

Introduction: The effects of alpha synuclein, parkin mutation and pharmacological agents have been studied in the Drosophila model.

Methods: The effect of cabergoline was studied on the cognitive impairments exhibited by the transgenic Drosophila expressing human alpha-synuclein in the neurons. The PD flies were allowed to feed on the diet having 0.5, 1 and 1.5 μM of cabergoline.

Results and Discussion: The exposure of cabergoline not only showed a dose-dependent significant delay in the cognitive impairments but also prevented the loss of dopaminergic neurons. Molecular docking studies showed the positive interaction between cabergoline and alpha-synuclein.

Conclusion: The results suggest a protective effect of cabergoline against the cognitive impairments.

背景：帕金森氏病是一种常见的神经退行性疾病，其特征是黑质致密部中的多巴胺能神经元选择性丢失。

简介：在果蝇模型中已研究了α突触核蛋白，帕金突变和药理作用。

方法：研究卡麦角林对神经元中表达人α-突触核蛋白的转基因果蝇表现出的认知障碍的影响。允许PD果蝇以具有0.5、1和1.5μM卡麦角林的饮食为食。

结果与讨论：卡麦角林的暴露不仅显示出认知障碍中剂量依赖性的显着延迟，而且还防止了多巴胺能神经元的丢失。分子对接研究表明卡麦角林与α-突触核蛋白之间存在正向相互作用。

结论：结果表明卡麦角林对认知障碍具有保护作用。