The cyclic nucleotides 3′,5′-adenosine monophosphate (cyclic AMP) signalling system underlies the control of many biological events and disease processes in man. Cyclic AMP is synthesised by adenylate cyclase (AC) enzymes in order to activate effector proteins and it is then degraded by phosphodiesterase (PDE) enzymes. Research in recent years has identified a range of cell-type-specific cyclic AMP effector proteins, including protein kinase A (PKA), exchange factor directly activated by cyclic AMP (EPAC), cyclic AMP responsive ion channels (CICs), and the Popeye domain containing (POPDC) proteins, which participate in different signalling mechanisms. In addition, recent advances have revealed new mechanisms of action for cyclic AMP signalling, including new effectors and new levels of compartmentalization into nanodomains, involving AKAP proteins and targeted adenylate cyclase and phosphodiesterase enzymes. This Special Issue contains 21 papers that highlight advances in our current understanding of the biology of compartmentlised cyclic AMP signalling. This ranges from issues of pathogenesis and associated molecular pathways, functional assessment of novel nanodomains, to the development of novel tool molecules and new techniques for imaging cyclic AMP compartmentilisation. This editorial aims to summarise these papers within the wider context of cyclic AMP signalling.

中文翻译：

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“循环AMP信号的新进展”特刊——社论综述

环核苷酸 3',5'-单磷酸腺苷 (环 AMP) 信号系统是控制人类许多生物事件和疾病过程的基础。环状 AMP 由腺苷酸环化酶 (AC) 合成以激活效应蛋白，然后被磷酸二酯酶 (PDE) 酶降解。近年来的研究已经确定了一系列细胞类型特异性环 AMP 效应蛋白，包括蛋白激酶 A (PKA)、由环 AMP 直接激活的交换因子 (EPAC)、环 AMP 响应离子通道 (CIC) 和大力水手结构域 (POPDC) 蛋白，参与不同的信号传导机制。此外，最近的进展揭示了循环 AMP 信号传导的新作用机制，包括新的效应子和新水平的纳米域划分，涉及 AKAP 蛋白和靶向腺苷酸环化酶和磷酸二酯酶。本期特刊包含 21 篇论文，重点介绍了我们目前对分隔环 AMP 信号传导生物学的理解方面的进展。这包括从发病机制和相关分子途径的问题、新型纳米结构域的功能评估，到开发新型工具分子和成像环状 AMP 区室化的新技术。这篇社论旨在在更广泛的循环 AMP 信号传递范围内总结这些论文。新型纳米结构域的功能评估，开发新型工具分子和成像环状 AMP 区室化的新技术。这篇社论旨在在更广泛的循环 AMP 信号传递范围内总结这些论文。新型纳米结构域的功能评估，开发新型工具分子和成像环状 AMP 区室化的新技术。这篇社论旨在在更广泛的循环 AMP 信号传递范围内总结这些论文。