当前位置: X-MOL 学术npj Biofilms Microbiomes › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Vaginal microbiota and human papillomavirus infection among young Swedish women
npj Biofilms and Microbiomes ( IF 9.2 ) Pub Date : 2020-10-12 , DOI: 10.1038/s41522-020-00146-8
Liqin Cheng 1 , Johanna Norenhag 2 , Yue O O Hu 1 , Nele Brusselaers 1 , Emma Fransson 1, 2 , Andreas Ährlund-Richter 3 , Unnur Guðnadóttir 1 , Pia Angelidou 1 , Yinghua Zha 1 , Marica Hamsten 1 , Ina Schuppe-Koistinen 1, 4 , Matts Olovsson 2 , Lars Engstrand 1, 4 , Juan Du 1
Affiliation  

Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. To define the HPV-associated microbial community among a high vaccination coverage population, we carried out a cross-sectional study with 345 young Swedish women. The microbial composition and its association with HPV infection, including 27 HPV types, were analyzed. Microbial alpha-diversity was found significantly higher in the HPV-infected group (especially with oncogenic HPV types and multiple HPV types), compared with the HPV negative group. The vaginal microbiota among HPV-infected women was characterized by a larger number of bacterial vaginosis-associated bacteria (BVAB), Sneathia, Prevotella, and Megasphaera. In addition, the correlation analysis demonstrated that twice as many women with non-Lactobacillus-dominant vaginal microbiota were infected with oncogenic HPV types, compared with L. crispatus-dominated vaginal microbiota. The data suggest that HPV infection, especially oncogenic HPV types, is strongly associated with a non-Lactobacillus-dominant vaginal microbiota, regardless of age and vaccination status.



中文翻译:

瑞典年轻女性的阴道微生物群和人乳头瘤病毒感染

人乳头瘤病毒 (HPV) 感染是最常见的性传播疾病之一。为了确定高疫苗接种覆盖人群中 HPV 相关的微生物群落,我们对 345 名瑞典年轻女性进行了横断面研究。分析了微生物组成及其与 HPV 感染的关联,包括 27 种 HPV 类型。与 HPV 阴性组相比,HPV 感染组(尤其是致癌 HPV 类型和多种 HPV 类型)的微生物 α 多样性显着更高。HPV感染的妇女中阴道微生物群的特征是一个更大数量的细菌性阴道炎相关的细菌的(BVAB),Sneathia普雷沃,和巨球形菌属. 此外,相关性分析表明,与卷曲乳杆菌主导的阴道微生物群相比,非乳酸杆菌主导的阴道微生物群的女性感染致癌 HPV 类型的数量是其两倍。数据表明,无论年龄和疫苗接种状况如何,HPV 感染,尤其是致癌 HPV 类型,都与非乳酸杆菌占优势的阴道微生物群密切相关。

更新日期:2020-10-12
down
wechat
bug