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Optimizing CARs for ocular delivery
Nature Cancer ( IF 22.7 ) Pub Date : 2020-10-12 , DOI: 10.1038/s43018-020-00127-y
Anandani Nellan 1, 2 , Terry J Fry 1, 2
Affiliation  

Effective methods for treating retinoblastoma while preserving vision are an unmet clinical need. Subretinal delivery of a hydrogel containing T cells that secrete the cytokine IL-15 and express a chimeric antigen receptor directed at the ganglioside protein GD2 completely controls retinoblastoma in immunocompromised mice, with no obvious damage to the surrounding retina.

中文翻译:

优化用于眼部递送的 CAR

在保持视力的同时治疗视网膜母细胞瘤的有效方法是未满足的临床需求。含有分泌细胞因子 IL-15 并表达针对神经节苷脂蛋白 GD2 的嵌合抗原受体的 T 细胞的水凝胶的视网膜下递送完全控制了免疫功能低下小鼠的视网膜母细胞瘤,对周围视网膜没有明显损伤。
更新日期:2020-10-12
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