Abstract

Purpose

To explore the association of demographic characteristics, clinical symptoms and the fear of the disease progression factors with the physical and mental summary components of the health-related of life (HRQoL) of the papillary thyroid microcarcinoma (PTMC) patients undergoing radiofrequency ablation (RFA).

Methods

123 PTMC survivors undergoing RFA were enrolled in this study from October 2019 to March 2020. Demographic, clinical symptoms and the fear of the disease progression data were collected. SF-36, THYCA-QoL and FoP-Q-SF were used to evaluate the HRQoL of patients, clinical symptoms and the fear of disease progression. A multivariate regression model was performed to evaluate the association between the independent variable and the HRQoL variable.

Results

The average self-reported HRQoL score was 81.17 ± 15.48 for the PCS and 73.40 ± 18.03 for the MCS. The multivariate linear regression model shows that the factors related to a poorer PCS were dependent for the female patients, the symptoms of neuromuscular and the throat/mouth, the fear of disease progression; the psychological disorder, symptoms of throat/mouth, inability to concentrate were related to worse scores for the MCS. The condition that was most strongly related to a poorer HRQoL (in both PCS and MCS) was the fear of their physical health.

Conclusions

The factors related to significantly worse HRQoL scores across PCS and MCS for PTMC survivors include the female gender, the symptoms of neuromuscular and the throat/mouth, the psychological disorder, inability to concentrate, and the fear of their own physical health. Identification, management, and prevention of these factors are critical to improving the HRQoL of patients.

中文翻译：

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甲状腺射频乳头状甲状腺癌患者健康相关生活质量的相关因素：横断面患病率研究

摘要

目的

探讨人口统计学特征，临床症状和疾病进展因素的恐惧与接受射频消融（RFA）的甲状腺乳头状微癌（PTMC）患者的健康相关生活（HRQoL）的身体和精神摘要成分之间的关​​系。

方法

从2019年10月至2020年3月，本研究招募了123名接受RFA的PTMC幸存者。收集了人口统计学，临床症状和对疾病进展的担忧。SF-36，THYCA-QoL和FoP-Q-SF用于评估患者的HRQoL，临床症状和对疾病进展的恐惧。进行了多元回归模型以评估自变量与HRQoL变量之间的关联。

结果

PCS自我报告的HRQoL平均得分为110.17±15.48，MCS为73.40±18.03。多元线性回归模型显示，与PCS较差有关的因素取决于女性患者，神经肌肉和喉咙/嘴巴的症状，对疾病进展的恐惧。心理障碍，喉咙/嘴巴症状，无法集中注意力与MCS评分较差有关。与较差的HRQoL（在PCS和MCS中）最密切相关的疾病是对他们身体健康的恐惧。

结论

与PTMC幸存者的PCS和MCS的HRQoL分数显着降低有关的因素包括女性，性别，神经肌肉和喉咙/嘴巴的症状，心理障碍，无法专心以及对自己身体健康的恐惧。识别，管理和预防这些因素对于改善患者的HRQoL至关重要。