The trifluoromethyl (CF₃) group is an advantageous structural motif in various biologically active molecules as well as materials, which is depicted by steadily increasing demand from the industries involved in drug discovery, agrochemicals and material development. β‐trifluoromethyl α,β‐unsaturated carbonyl compounds constitute a very efficient building blocks as starting material in the synthesis of fluorinated molecules. Their usage for the synthesis of various heterocycles and organic molecules bearing stereogenic carbon containing CF₃ motif has received significant attention during the recent times. This review provides the existing methods for the synthesis of β‐substituted trifluoromethyl‐α,β‐unsaturated ketones and the efforts made by researchers for the synthetic development through various reactions by employing them as synthetic building blocks for trifluoromethylated organic scaffolds.

中文翻译：

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β-三氟甲基α，β-不饱和酮：各种三氟甲基化分子的有效组成部分

三氟甲基（CF ₃）基团是各种生物活性分子和材料中的一种有利的结构基序，其特点是涉及药物发现，农用化学品和材料开发的行业稳定增长的需求。β-三氟甲基α，β-不饱和羰基化合物是合成氟化分子的起始原料，是非常有效的结构单元。近年来，它们用于合成各种带有立体碳的含有CF ₃基序的杂环和有机分子的用途受到了广泛的关注。这篇综述提供了合成β的现有方法取代的三氟甲基-α，β-不饱和酮以及研究人员通过将其用作三氟甲基化有机支架的合成构件，通过各种反应进行合成开发的努力。