Ganoderma is one of the common medicinal mushrooms in traditional Chinese medicine. Previous researches have unveiled the multifaceted biological activity of Ganoderma extract. Ganoderma tsugae has been investigated the potential on curing prostate, colon, lung, epidermoid, breast and ovarian cancers, but not including endometrial cancer. Endometrial cancer is a gynecological malignant tumor with serious drug resistance problem in clinical cancer treatment. This study aimed to demonstrate the first study of Ganoderma on treating endometrial cancer. The Ganoderma tsugae ethanol extract (GTEE) could suppress the proliferation of endometrial cancer cells HEC-1-A, KLE, and AN3 CA. GTEE also induced G1/S phase arrest and mitochondria-mediated apoptosis in endometrial cancer cells. Furthermore, the Akt signaling pathway could be suppressed by GTEE. Therefore, our results suggest for the first time that GTEE has the potential to be an adjuvant therapeutic agent in the treatment of endometrial cancer.

中文翻译：

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松茸灵芝通过Akt信号通路抑制子宫内膜癌细胞增殖

灵芝是中药中常见的药用蘑菇之一。先前的研究揭示了灵芝提取物的多方面生物活性。已经研究了松茸灵芝治疗前列腺癌、结肠癌、肺癌、表皮样癌、乳腺癌和卵巢癌的潜力，但不包括子宫内膜癌。子宫内膜癌是临床癌症治疗中存在严重耐药问题的妇科恶性肿瘤。本研究旨在证明灵芝治疗子宫内膜癌的首次研究。松茸乙醇提取物 (GTEE) 可抑制子宫内膜癌细胞 HEC-1-A、KLE 和 AN3 CA 的增殖。GTEE 还诱导子宫内膜癌细胞的 G1/S 期停滞和线粒体介导的细胞凋亡。此外，Akt 信号通路可以被 GTEE 抑制。