Myosin VI is a minus end-directed actin motor protein that fulfils several roles in the cell. The interaction of myosin VI with its cellular cargoes is dictated by the presence of binding domains at the C-terminus of the protein. In this review, we describe how alternative splicing and structural and conformational changes modulate the plasticity of the myosin VI interactome. Recent findings highlight how the various partners can cooperate or compete for binding to allow a precise temporal and spatial regulation of myosin VI recruitment to different cellular compartments, where its motor or anchor function is needed.

中文翻译：

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肌组学：肌球蛋白VI结构和功能可塑性

肌球蛋白 VI 是负端定向的肌动蛋白运动蛋白，在细胞中发挥多种作用。肌球蛋白 VI 与其细胞货物的相互作用取决于蛋白质 C 端结合域的存在。在这篇综述中，我们描述了选择性剪接以及结构和构象变化如何调节肌球蛋白 VI 相互作用组的可塑性。最近的研究结果强调了各种合作伙伴如何合作或竞争结合以允许肌球蛋白 VI 募集到不同细胞区室的精确时间和空间调节，在这些区室中需要其运动或锚定功能。