Predictive biomarkers can facilitate optimal patient selection for targeted cancer therapies. In this issue of Cancer Cell, Ros et al. show the utility of noninvasive metabolic imaging of labeled carbon transfer from pyruvate to lactate to detect early response and FOXM1-mediated resistance to PI3K inhibition in estrogen-receptor-positive breast cancer.

中文翻译：

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乳酸盐增强乳腺癌中PI3K抑制剂的耐药性

预测性生物标志物可以促进针对靶向癌症治疗的最佳患者选择。在本期《癌细胞》中，罗斯等人。展示了标记的碳从丙酮酸转移到乳酸的无创代谢成像在检测雌激素受体阳性乳腺癌的早期反应和FOXM1介导的对PI3K抑制的抗性中的实用性。