Cellular plasticity contributes to intratumoral heterogeneity, metastatic spread, and treatment resistance of cancers. In this issue of Cancer Cell, Gabitova-Cornell et al. identify the potential to inadvertently develop an undifferentiated and more aggressive pancreas cancer with agents commonly prescribed to manage heart disease risk.

中文翻译：

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胆固醇生物合成影响胰腺癌的亚型特异性和可塑性

细胞可塑性导致肿瘤内异质性、转移扩散和癌症的治疗耐药性。在本期的Cancer Cell中，Gabitova-Cornell 等人。使用通常用于控制心脏病风险的药物，确定无意中发展为未分化且更具侵袭性的胰腺癌的可能性。