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Arterial spin labeling hyperperfusion in seizures associated with non-ketotic hyperglycaemia: is it merely a post-ictal phenomenon?
Neurological Sciences ( IF 3.3 ) Pub Date : 2020-10-12 , DOI: 10.1007/s10072-020-04815-6
Sabarish Sekar , Selvadasan Vinayagamani , Bejoy Thomas , Chandrasekharan Kesavadas

A 53-year-old chronic uncontrolled diabetic patient presented with one episode of generalized seizures followed by drowsiness and post-ictal confusion. MR imaging at admission revealed left temporal subcortical T2/FLAIR hypointensities with overlying cortical T2/FLAIR hyperintensities and increased perfusion on arterial spin labeling (ASL). Follow-up imaging at 4- and 8-week interval revealed persistent ASL hyperperfusion with significant resolution of conventional MR imaging findings. Delayed persistent ASL hyperperfusion suggests that hyperglycemia-induced increased blood-brain barrier permeability rather than a mere post-ictal phenomenon in non-ketotic hyperglycemia (NKH) and may result in long-term cognitive disturbances.



中文翻译:

与非酮症高血糖相关的癫痫发作中的动脉自旋标记过度灌注:这仅仅是发作后的现象吗?

一名53岁的慢性非控制性糖尿病患者,发作了一次全身性癫痫发作,随后出现嗜睡和发作后精神错乱。入院时的MR成像显示左侧颞下皮质T2 / FLAIR低强度伴有皮质T2 / FLAIR高强度,并在动脉自旋标记(ASL)上灌注增加。每隔4周和8周进行一次随访成像,发现持续的ASL血流灌注明显改善了常规MR成像的发现。延迟性持续性ASL过度灌注提示,高血糖症引起的血脑屏障通透性增加,而不是非酮症性高血糖症(NKH)仅有单纯的发作后现象,并可能导致长期的认知障碍。

更新日期:2020-10-12
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