Journal of Materials Science: Materials in Medicine ( IF 3.7 ) Pub Date : 2020-10-12 , DOI: 10.1007/s10856-020-06444-z Huafang Li 1 , Chao Shen 2, 3 , Dike Ruan 2 , Xiwei Liu 4 , Xiaokang Li 3 , Shuo Guo 3 , Zheng Guo 3
In the present study, the microstructure, mechanical properties, corrosion behavior, wettability, haemocompatibility, and cytocompatibility of the as-cast and as-rolled biodegradable Zn-1Mg-0.1Ca and Zn-1Mg-0.5Ca have been systematically investigated to evaluate their feasibility as potential biodegradable materials. The results demonstrated that the Zn-1Mg-0.1Ca have significantly improved mechanical properties, with the yield strength (YS), ultimate tensile strength (UTS), and elongation of as-rolled Zn-1Mg-0.1Ca are (209.04 ± 28.31) MPa, (331.51 ± 40.06) MPa, and (35.43 ± 3.53)%, respectively. Wettability test results demonstrated that the Zn-1Mg-0.1Ca and Zn-1Mg-0.5Ca have hydrophilic surfaces that can enhance cell responses and tissue-implant interactions. The haemocompatibility evaluation showed that the hemolysis ratio of Zn-1Mg-0.1Ca have a low hemolysis ratio of 0.6%; the platelets remain sphere morphology and are not activated. High cell viability indicates the cytocompatibility of the as-rolled Zn-1Mg-0.1Ca alloy. The Zn-1Mg-0.1Ca alloy can be considered as new suitable biodegradable Zn-based alloys for further biomedical applications.
中文翻译:
可生物降解的 Zn-1Mg-0.1Ca 和 Zn-1Mg-0.5Ca 的微观结构、力学性能和体外行为
在本研究中,系统地研究了铸态和轧态可生物降解 Zn-1Mg-0.1Ca 和 Zn-1Mg-0.5Ca 的微观结构、机械性能、腐蚀行为、润湿性、血液相容性和细胞相容性,以评估它们的性能。作为潜在的可生物降解材料的可行性。结果表明,Zn-1Mg-0.1Ca具有显着改善的力学性能,其屈服强度(YS)、极限抗拉强度(UTS)和轧制态Zn-1Mg-0.1Ca的延伸率为(209.04±28.31) MPa、(331.51 ± 40.06) MPa 和 (35.43 ± 3.53)%。润湿性测试结果表明,Zn-1Mg-0.1Ca 和 Zn-1Mg-0.5Ca 具有亲水性表面,可以增强细胞反应和组织植入物相互作用。血液相容性评价表明Zn-1Mg-0. 1Ca具有0.6%的低溶血率;血小板保持球体形态,不被激活。高细胞活力表明轧制态 Zn-1Mg-0.1Ca 合金的细胞相容性。Zn-1Mg-0.1Ca 合金可被认为是一种适用于进一步生物医学应用的新型可生物降解锌基合金。