当前位置: X-MOL 学术J. Assist. Reprod. Genet. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Altered evolution: are reproductive endocrinology and infertility specialists ready for the genetically engineered future?
Journal of Assisted Reproduction and Genetics ( IF 3.1 ) Pub Date : 2020-10-12 , DOI: 10.1007/s10815-020-01963-8
Zoran J Pavlovic 1 , Megan R Sax 2 , Ashley S Kim 3 , Alan H DeCherney 4
Affiliation  

Science, propelled forward by noble aspirations and, at times, human hubris, has the capacity to affect lives and alter the world in unanticipated ways. Even seemingly minor discoveries have repeatedly proven to have far reaching implications that experts within their respective fields could not have predicted. Nuclear technology is both a source of energy and a potential means of annihilation. The internet has both seamlessly connected the world but has also opened society to the misuse and manipulation of information. Both exemplify how new technologies have the potential for positive and negative outcomes that often go beyond what was initially intended. This is not a fault of science and innovation but rather an inherent occupational hazard as new discoveries exist within a gray zone between ignorance and comprehension. These gaps in our knowledge can only be filled over time as our knowledge expands. Innovations that were once seen as fringe, over time, become mainstream and that which was once revolutionary becomes a part of everyday life. Occasionally, a scientific advancement comes along that challenges societal norms and causes us to question what is feasible, acceptable, and ethical. Nowhere in the twenty-first century has this been more evident than within the fields of genetics and genetic engineering. As we gain a deeper understanding of the source code of life, from individual base pairs to epigenetic influences, the implications of new discoveries will go far beyond curing genetic diseases, and the possibilities will be endless. Reproductive endocrinology and infertility (REI) specialists utilize many tools including expanded carrier screening, preimplantation genetic testing, and embryo selection and have become some of the experts at the forefront of the ongoing genetic revolution. Now more than ever, there is a need for REIs to be trained in the fundamentals of genetics, exposed to novel gene sequencing and editing techniques, and involved in the coming ethical discussions in order to be prepared for the genetically engineered future.



中文翻译:

改变进化:生殖内分泌学和不孕不育专家准备好迎接基因工程的未来了吗?

科学在崇高的愿望和有时的人类傲慢的推动下向前发展,有能力以意想不到的方式影响生活和改变世界。即使看似微不足道的发现也一再被证明具有各自领域专家无法预测的深远影响。核技术既是一种能源,也是一种潜在的毁灭手段。互联网既无缝连接了世界,也让社会容易滥用和操纵信息。两者都体现了新技术如何可能产生积极和消极的结果,而这些结果往往超出最初的预期。这不是科学和创新的错误,而是一种固有的职业危害,因为新发现存在于无知和理解之间的灰色地带。随着我们知识的扩展,我们知识中的这些空白只能随着时间的推移而被填补。随着时间的推移,曾经被视为边缘的创新将成为主流,曾经具有革命性的创新也将成为日常生活的一部分。有时,科学进步会挑战社会规范,让我们质疑什么是可行的、可接受的和道德的。在二十一世纪,这一点在遗传学和基因工程领域最为明显。随着我们对生命源代码(从个体碱基对到表观遗传影响)有了更深入的了解,新发现的意义将远远超出治愈遗传疾病的范围,并且可能性将是无限的。生殖内分泌和不孕不育 (REI) 专家利用多种工具,包括扩大携带者筛查、植入前基因检测和胚胎选择,并已成为当前基因革命前沿的专家之一。现在,REI 比以往任何时候都更需要接受遗传学基础知识的培训,接触新的基因测序和编辑技术,并参与即将到来的伦理讨论,以便为基因工程的未来做好准备。

更新日期:2020-10-12
down
wechat
bug