Purpose

To evaluate the effect of controlled ovarian hyperstimulation length and total gonadotropin (GN) dose on recipient live birth rate (LBR) in fresh donor oocyte cycles.

Methods

Data was obtained from SART CORS on all fresh donor oocyte GnRH antagonist cycles (n = 1049) between 2014 and 2015 which resulted in a single embryo transferred. Donor and recipient demographic information and cycle characteristics were extracted. Binomial regression was used to estimate LBR with respect to days of stimulation (DOS) and total GN dose. Multivariate analysis was performed to evaluate these relationships after controlling for confounders.

Results

Overall LBR in fresh donor oocyte cycles was 57%. Average stimulation length was 14.3 ± 4.9 days, and total GN dose was 2464 ± 1062 IU. On univariate analysis, neither days of stimulation (p = 0.5) nor total GN dose (p = 0.57) was independently correlated with LBR. However, in prolonged stimulations (> 15 days) with high total GN dose (> 3000 IU), as both the cycle length and total GN dose increased, LBR significantly decreased from 63.81 to 48.15% (p = 0.02) and from 67.61 to 48.15% (p = 0.01), respectively. Multivariate analysis showed no significant effect of either DOS or total GN dose on LBR.

Conclusions

LBR is significantly decreased in fresh donor oocyte cycles when cycles are prolonged with high total GN dose. However, after controlling for confounders neither DOS nor total GN dose significantly affects LBR.

中文翻译：

---

卵巢刺激的时间长度不会影响新鲜供体卵母细胞周期中的活产率：SART CORS 研究

目的

评估受控卵巢过度刺激长度和总促性腺激素 (GN) 剂量对新鲜供体卵母细胞周期中受者活产率 (LBR) 的影响。

方法

从 SART CORS 获得了 2014 年至 2015 年间所有新鲜供卵母细胞 GnRH 拮抗剂周期（n  = 1049）的数据，该周期导致单个胚胎移植。提取了捐赠者和接受者的人口统计信息和周期特征。使用二项式回归来估计相对于刺激天数 (DOS) 和总 GN 剂量的 LBR。在控制混杂因素后，进行多变量分析来评估这些关系。

结果

新鲜供体卵母细胞周期中的总体 LBR 为 57%。平均刺激长度为 14.3 ± 4.9 天，总 GN 剂量为 2464 ± 1062 IU。在单变量分析中，刺激天数 ( p  = 0.5) 和总 GN 剂量 ( p  = 0.57) 与 LBR 均不独立相关。然而，在高总 GN 剂量 (> 3000 IU) 的长时间刺激（> 15 天）中，随着周期长度和总 GN 剂量的增加，LBR 显着下降，从 63.81% 降至 48.15% ( p  = 0.02)，从 67.61 降至 48.15 %（p  = 0.01）。多变量分析显示 DOS 或总 GN 剂量对 LBR 没有显着影响。

结论

当高总 GN 剂量延长周期时，新鲜供体卵母细胞周期中的 LBR 显着降低。然而，在控制混杂因素后，DOS 和 GN 总剂量均不会显着影响 LBR。