Abstract—Oxidative stress is among the main causes of developing severe complications in diabetes mellitus (DM). Existing pharmaceuticals, although efficient in reducing the blood glucose level, infrequently demonstrate antioxidant properties. On the other hand, there are many reliable reports about a broad range of biological activity exhibited by photobiomodulation therapy (PBMT). Its potential sugar-lowering and antioxidant action makes this type of therapy a promising option for the treatment of DM and its complications. The effect of PBMT on the state of the antioxidant defense system in blood leukocytes was investigated in rats with streprozocin-induced DM. This study has shown that the PBMT increased superoxide dismutase (SOD) activity in rats with DM and normalized the content of oxidative stress markers (thiobarbituric acid (TBA)-active products, oxidatively modified proteins, and protein glycation end products).

摘要-氧化应激是导致糖尿病（DM）严重并发症的主要原因之一。现有的药物尽管能有效降低血糖水平，但很少能显示出抗氧化性能。另一方面，关于光生物调节疗法（PBMT）表现出的广泛的生物活性，有许多可靠的报道。其潜在的降糖和抗氧化作用使这种疗法成为治疗DM及其并发症的有前途的选择。考察了PBMT对链脲佐菌素诱导的DM大鼠血液中白细胞抗氧化防御系统状态的影响。这项研究表明，PBMT可增加患有DM的大鼠的超氧化物歧化酶（SOD）活性，并使氧化应激标记物（硫代巴比妥酸（TBA）活性产物，