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Effect of Gene SFU1 on Riboflavin Synthesis in Flavinogenic Yeast Candida famata
Cytology and Genetics ( IF 0.5 ) Pub Date : 2020-10-12 , DOI: 10.3103/s0095452720050060
Y. Petrovska , O. Lyzak , K. Dmytruk , A. Sibirny

Abstract—Riboflavin or vitamin B2 is a necessary component for all living organisms since it is the precursor of flavin coenzymes FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide), which are involved in numerous enzymatic reactions. Flavinogenic yeast Candida famata overproduces riboflavin under iron starvation; however, regulation of this process is poorly understood. Regulatory gene SEF1 encoding the transcription activator has been identified. Its deletion blocks yeast’s ability to overproduce riboflavin under iron starvation. It is known that, in the pathogenic flavinogenic yeast C. albicans, Sfu1 (GATA-type transcription factor) represses SEF1. It is demonstrated in this study that deletion of the SEF1 gene in wild type C. famata leads to overproduction of riboflavin.



中文翻译:

SFU1基因对产黄酵母酵母假丝酵母核黄素合成的影响

摘要—核黄素或维生素B 2是所有活生物体的必需成分,因为它是黄素辅酶FMN(黄素单核苷酸)和FAD(黄素腺嘌呤二核苷酸)的前体,它们参与许多酶促反应。黄铁酵母念珠菌在铁饥饿时过量生产核黄素;但是,对此过程的法规了解甚少。已经鉴定出编码转录激活因子的调节基因SEF1。它的缺失阻止了酵母在铁饥饿状态下过量生产核黄素的能力。已知在致病性黄原酵母白色念珠菌中,Sfu1(GATA型转录因子)抑制SEF1。这项研究表明,野生型C. famata中SEF1基因的缺失会导致核黄素的过量生产。

更新日期:2020-10-12
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