Synthesis of enantiomerically pure (2S)-(+)-heptan-2-ol and (2S)-(+)-octan-2-ol by bioreduction of heptan-2-one and octan-2-one using Daucus carota cells has been studied. Optimization of bioreduction conditions has been carried out in the presence of various exogenous reducing agents (ethanol, isopropanol, glucose). Conditions allowing to obtain (2S)-(+)-heptan-2-ol with 91% yield and optical purity 98% ee and (2S)-(+)-octan-2-ol in 95% yield and > 99% ee have been found.

中文翻译：

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Daucus carota细胞催化的庚二酮和octan-2-one的对映选择性生物还原

对映体纯的（2S）-（+）-庚-2-醇和（2S）-（+）-octan-2-ol的合成是利用Daucus carota细胞对庚烷-2-酮和辛烷-2-酮进行生物还原而实现的经过研究。在各种外源性还原剂（乙醇，异丙醇，葡萄糖）的存在下，已经进行了生物还原条件的优化。条件允许以91％的产率和98％ee的光学纯度获得（2S）-（+）-庚-2-醇和ee的95％和> 99％ee的（2S）-（+）-octan-2-ol被发现。