This study aimed to analyze the incidence of early postpartum dyslipidemia and its potential predictors in women with a history of gestational diabetes mellitus (GDM). This was a retrospective study. Five hundred eighty-nine women diagnosed with GDM were enrolled and followed up at 6–12 weeks after delivery. A 75 g oral glucose tolerance test (OGTT) and lipid levels were performed during mid-trimester and the early postpartum period. Participants were divided into the normal lipid group and dyslipidemia group according to postpartum lipid levels. Demographic and metabolic parameters were analyzed. Multiple logistic regression was performed to analyze the potential predictors for early postpartum dyslipidemia. A receiver operating characteristic curve (ROC) was calculated to determine the cut-off values. A total of 38.5% of the 589 women developed dyslipidemia in early postpartum and 60% of them had normal glucose metabolism. Delivery age, systolic blood pressure (SBP), glycated hemoglobin (HbA1c) and low-density lipoprotein cholesterol (LDL-C) were independent predictors of early postpartum dyslipidemia in women with a history of GDM. The cut-offs of maternal age, SBP, HbA1c values, and LDL-C levels were 35 years, 123 mmHg, 5.1%, and 3.56 mmol/L, respectively. LDL-C achieved a balanced mix of high sensitivity (63.9%) and specificity (69.2%), with the highest area under the receiver operating characteristic curve (AUC) (0.696). When LDL-C was combined with age, SBP, and HbA1c, the AUC reached to 0.733. A lipid metabolism evaluation should be recommended in women with a history of GDM after delivery, particularly those with a maternal age > 35 years, SBP > 123 mmHg before labor, HbA1c value > 5.1%, or LDL-C levels > 3.56 mmol/L in the second trimester of pregnancy.

中文翻译：

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有妊娠糖尿病史的女性妊娠期间早期产后血脂异常及其潜在预测因素

本研究旨在分析有妊娠期糖尿病 (GDM) 病史的女性早期产后血脂异常的发生率及其潜在预测因素。这是一项回顾性研究。589 名诊断患有 GDM 的女性被纳入研究，并在产后 6-12 周进行随访。在妊娠中期和产后早期进行 75 g 口服葡萄糖耐量试验 (OGTT) 和血脂水平。根据产后血脂水平将参与者分为血脂正常组和血脂异常组。分析了人口统计学和代谢参数。进行多重逻辑回归分析早期产后血脂异常的潜在预测因素。计算受试者工作特征曲线（ROC）以确定截止值。589名妇女中，共有38.5%的妇女在产后早期出现血脂异常，其中60%的妇女糖代谢正常。分娩年龄、收缩压 (SBP)、糖化血红蛋白 (HbA1c) 和低密度脂蛋白胆固醇 (LDL-C) 是有 GDM 病史的女性早期产后血脂异常的独立预测因素。母亲年龄、SBP、HbA1c 值和 LDL-C 水平的截止值分别为 35 岁、123 mmHg、5.1% 和 3.56 mmol/L。LDL-C 实现了高灵敏度 (63.9%) 和特异度 (69.2%) 的平衡组合，受试者工作特征曲线下面积 (AUC) 最高 (0.696)。当 LDL-C 与年龄、SBP 和 HbA1c 结合时，AUC 达到 0.733。对于有 GDM 病史的女性，尤其是产后年龄 > 35 岁、产前 SBP > 123 mmHg、HbA1c 值 > 5.1% 或 LDL-C 水平 > 3.56 mmol/L 的女性，应建议进行脂质代谢评估在怀孕中期。