Chronic neuroinflammation associated with neurodegenerative disorders has been reported to be prevented by dietary components. Particularly, dietary (poly)phenols have been identified as having anti-inflammatory and neuroprotective actions, and their ingestion is considered a major preventive factor for such disorders. To assess the relation between (poly)phenol classes and their bioactivity, we used five different raspberry genotypes, which were markedly different in their (poly)phenol profiles within a similar matrix. In addition, gastro-intestinal bio-accessible fractions were produced, which simulate the (poly)phenol metabolites that may be absorbed after digestion, and evaluated for anti-inflammatory potential using LPS-stimulated microglia. Interestingly, the fraction from genotype 2J19 enriched in ellagitannins, their degradation products and ellagic acid, attenuated pro-inflammatory markers and mediators CD40, NO, TNF-α, and intracellular superoxide via NF-κB, MAPK and NFAT pathways. Importantly, it also increased the release of the anti-inflammatory cytokine IL-10. These effects contrasted with fractions richer in anthocyanins, suggesting that ellagitannins and its derivatives are major anti-inflammatory (poly)phenols and promising compounds to alleviate neuroinflammation

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富含鞣花单宁和鞣花酸衍生物的生物可及性树莓提取物具有抗神经炎特性

据报道，饮食成分可预防与神经退行性疾病相关的慢性神经炎症。特别地，饮食中的（多）酚被鉴定为具有抗炎和神经保护作用，并且其摄入被认为是这种疾病的主要预防因素。为了评估（多）酚类与它们的生物活性之间的关系，我们使用了五种不同的覆盆子基因型，它们在相似的基质中的（多）酚类特征显着不同。另外，产生胃肠道生物可及级分，其模拟消化后可能吸收的（多）苯酚代谢产物，并使用LPS刺激的小胶质细胞评估其抗炎潜力。有趣的是，来自基因型2J19的部分富含鞣花单宁，它们的降解产物和鞣花酸，通过NF-κB，MAPK和NFAT途径减弱了促炎标记和CD40，NO，TNF-α和细胞内超氧化物的介体。重要的是，它也增加了抗炎细胞因子IL-10的释放。这些作用与富含花青素的馏分形成对比，表明鞣花单宁及其衍生物是主要的抗炎（多）酚类，并且是缓解神经炎症的有前途的化合物