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Monodispersity of Poly(ethylene glycol) Matters for Low-Fouling Coatings
ACS Macro Letters ( IF 5.8 ) Pub Date : 2020-10-09 , DOI: 10.1021/acsmacrolett.0c00557
Peiyu Zhang 1 , Zhonghe Zhang 1 , Donglei Wang 1 , Jingcheng Hao 1 , Jiwei Cui 1, 2
Affiliation  

Poly(ethylene glycol) (PEG) is the most used hydrophilic polymer for low-fouling coatings to minimize nonspecific interactions. The PEG molecular weight or its length as well as surface density are typically considered as the main impacts on the control over low-fouling properties. However, the influence of PEG monodispersity on such investigations is typically ignored and rarely reported. Herein, we report the assembly of PEGylated coatings on planar surfaces and Au nanorods (AuNRs) using a series of monodisperse PEG (Mono-PEG) with exact molecular weights and commonly used polydisperse PEG (Poly-PEG) to investigate the effect of the PEG molecular weight and monodispersity on the low-fouling properties. Nonspecific interactions with proteins or cells on PEGylated planar surfaces can be significantly reduced when Mono-PEG with a molecular weight of 752 Da and above is used, while a higher average molecular weight of 2000 Da is required for Poly-PEG-modified surfaces. Cell association of PEGylated AuNRs further confirms that a low molecular weight of Mono-PEG is sufficient to achieve low-fouling properties. This study provides an insight and general guidance into the engineering of low-fouling surfaces by the appropriate choice based on the PEG monodispersity and/or molecular weights.

中文翻译:

用于低污染涂料的聚(乙二醇)物质的单分散性

聚(乙二醇)(PEG)是用于低污染涂料的最常用的亲水性聚合物,可最大限度地减少非特异性相互作用。PEG分子量或其长度以及表面密度通常被认为是对低污染性能控制的主要影响。然而,PEG 单分散性对此类研究的影响通常被忽略且很少报道。在此,我们报告了使用一系列具有精确分子量的单分散 PEG (Mono-PEG) 和常用的多分散 PEG (Poly-PEG) 在平面表面和 Au 纳米棒 (AuNR) 上组装 PEG 化涂层来研究 PEG 的效果分子量和单分散性对低污染性能的影响。当使用分子量为 752 Da 及以上的 Mono-PEG 时,可以显着减少与 PEG 化平面表面上的蛋白质或细胞的非特异性相互作用,而 Poly-PEG 修饰的表面需要更高的平均分子量 2000 Da。PEG化的AuNRs的细胞结合进一步证实了低分子量的Mono-PEG足以实现低污染特性。This study provides an insight and general guidance into the engineering of low-fouling surfaces by the appropriate choice based on the PEG monodispersity and/or molecular weights.
更新日期:2020-10-21
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