ABSTRACT

Background

Multiple sclerosis (MS) is a chronic neurodegenerative and inflammatory disease. The adaptation to MS depends on the effectiveness of coping, which moderates the process of adaptation and psychological well-being.

Objectives

We aimed to analyze the coping strategies of an Argentinean population of patients with MS (PwMS) and their association with clinical variables and health-related quality of life (QoL).

Methods

A nationwide cross-sectional study. Screening instruments: Demographics and clinical data, coping strategies (Brief Coping Orientation to Problems Experienced, [COPE-28]), health-related QoL (MS Impact Scale, [MSIS-29]), Fatigue Severity Scale, and physical disability (self-administrated Expanded Disability Status Scale, [EDSS]).

Results

We included 249 PwMS. Most responders were female (74.7%) with a mean age at survey of 38.6 (±10.7) and had a MS duration of 7.3 years (range: 1–43 years) and a mean EDSS of 1.9 (±1.8). Younger age (r = −0.17), active MS (r = 0.25), higher fatigue (r = 0.22), MSIS-29 total (r = 0.34), MSIS-physical (r = 0.26), MSIS-psychological scores (r = 0.44), higher scores for perception of both severity of MS (r = 0.12) and wheelchair-dependency (r = 0.14) correlated significantly with the use of maladaptive coping strategies. However, active MS (β2.10, p = 0.01), MSIS-psychological score (β0.28, p < 0.0001), high education level (β − 1.15, p = 0.04), and EDSS (β − 0.84, p = 0.0001) were independent predictors of the utilization of maladaptive coping strategies after having applied multivariate analysis via linear regression.

Conclusions

Maladaptive coping strategies used by PwMS are associated with relevant clinical aspects of the disease and with worse health-related QoL scores.

中文翻译：

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阿根廷复发性多发性硬化患者的应对策略：与生活质量和临床特征的相关性

摘要

背景

多发性硬化症 (MS) 是一种慢性神经退行性和炎症性疾病。对 MS 的适应取决于应对的有效性，这会调节适应过程和心理健康。

目标

我们旨在分析阿根廷 MS 患者 (PwMS) 人群的应对策略及其与临床变量和健康相关生活质量 (QoL) 的关联。

方法

一项全国性的横断面研究。筛选工具：人口统计学和临床​​数据、应对策略（Brief Coping Orientation to Problems Experience, [COPE-28]）、健康相关 QoL（MS 影响量表，[MSIS-29]）、疲劳严重程度量表和身体残疾（自我- 管理的扩展残疾状态量表，[EDSS]）。

结果

我们包括了 249 个 PwMS。大多数应答者是女性 (74.7%)，调查时的平均年龄为 38.6 (±10.7) 岁，MS 持续时间为 7.3 年（范围：1-43 岁），平均 EDSS 为 1.9 (±1.8)。年龄较小 (r = -0.17)、活动性 MS (r = 0.25)、更疲劳 (r = 0.22)、MSIS-29 总分 (r = 0.34)、MSIS-身体 (r = 0.26)、MSIS-心理评分 (r = 0.44)，对 MS 严重程度 (r = 0.12) 和轮椅依赖 (r = 0.14) 的感知得分较高，与使用不良应对策略显着相关。然而，活动性 MS (β2.10, p = 0.01)、MSIS-心理评分 (β0.28, p < 0.0001)、高教育水平 (β − 1.15, p = 0.04) 和 EDSS (β − 0.84, p = 0.0001）是通过线性回归应用多变量分析后适应不良应对策略利用的独立预测因子。

结论

PwMS 使用的适应不良应对策略与疾病的相关临床方面以及与健康相关的 QoL 评分较差有关。