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In vivo imaging of neural circuit formation in the neonatal mouse barrel cortex
Development, Growth & Differentiation ( IF 2.5 ) Pub Date : 2020-10-08 , DOI: 10.1111/dgd.12693
Takuji Iwasato 1, 2
Affiliation  

Higher brain function in mammals primarily relies on complex yet sophisticated neuronal circuits in the neocortex. In early developmental stages, neocortical circuits are coarse. Mostly postnatally, the circuits are reorganized to establish mature precise connectivity, in an activity‐dependent manner. These connections underlie adult brain function. The rodent somatosensory cortex (barrel cortex) contains a barrel map in layer 4 (L4) and has been considered an ideal model for the study of postnatal neuronal circuit formation since the first report of barrels in 1970. Recently, two‐photon microscopy has been used for analyses of neuronal circuit formation in the mammalian brain during early postnatal development. These studies have further highlighted the mouse barrel cortex as an ideal model. In particular, the unique dendritic projection pattern of barrel cortex L4 spiny stellate neurons (barrel neurons) is key for the precise one‐to‐one functional relationship between whiskers and barrels and thus an important target of studies. In this article, I will review the morphological aspects of postnatal development of neocortical circuits revealed by recent two‐photon in vivo imaging studies of the mouse barrel cortex and other related works. The focus of this review will be on barrel neuron dendritic refinement during neonatal development.

中文翻译:

新生小鼠桶状皮层神经回路形成的体内成像

哺乳动物的高级大脑功能主要依赖于新皮质中复杂而复杂的神经元回路。在早期发育阶段,新皮质回路是粗糙的。大多数在出生后,电路被重组以建立成熟的精确连接,以依赖于活动的方式。这些联系是成人大脑功能的基础。啮齿动物体感皮层(桶皮层)在第 4 层 (L4) 中包含桶图,自 1970 年首次报告桶以来,它被认为是研究出生后神经元回路形成的理想模型。最近,双光子显微镜已被用于分析出生后早期发育过程中哺乳动物大脑中神经元回路的形成。这些研究进一步强调了小鼠桶状皮层是一种理想的模型。特别是,桶状皮层 L4 棘状星状神经元(桶状神经元)独特的树突投射模式是胡须和桶之间精确的一对一功能关系的关键,因此是研究的重要目标。在本文中,我将回顾最近对小鼠桶状皮层的双光子体内成像研究和其他相关工作揭示的新皮层回路出生后发育的形态学方面。本综述的重点将是新生儿发育过程中的桶状神经元树突细化。我将回顾最近小鼠桶状皮层的双光子体内成像研究和其他相关工作揭示的新皮层回路出生后发育的形态学方面。本综述的重点将是新生儿发育过程中的桶状神经元树突细化。我将回顾最近小鼠桶状皮层的双光子体内成像研究和其他相关工作揭示的新皮层回路出生后发育的形态学方面。本综述的重点将是新生儿发育过程中的桶状神经元树突细化。
更新日期:2020-11-09
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