About half the world's population is at risk of malaria, with Plasmodium falciparum malaria being responsible for the most malaria related deaths globally. Antimalarial drugs such as chloroquine and artemisinin are directed towards the proliferating intra‐erythrocytic stages of the parasite, which is responsible for all the clinical symptoms of the disease. These antimalarial drugs have been reported to function via multiple pathways, one of which induces DNA damage via the generation of free radicals and reactive oxygen species. An urgent need to understand the mechanistic details of drug response and resistance is highlighted by the decreasing clinical efficacy of the front line drug, Artemisinin.

中文翻译：

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恶性疟原虫复制因子C亚基1参与基因毒性应激反应

世界上约有一半人口面临疟疾风险，恶性疟原虫疟疾是全球与疟疾相关死亡人数最多的原因。抗疟药物如氯喹和青蒿素针对寄生虫的增殖红细胞内阶段，这是该疾病所有临床症状的原因。据报道，这些抗疟药通过多种途径发挥作用，其中一种途径通过自由基和活性氧的产生诱导 DNA 损伤。一线药物青蒿素的临床疗效下降凸显了了解药物反应和耐药机制细节的迫切需要。