Pediatric low‐grade gliomas were shown to be characterized by an array of distinct molecular aberrations. The recent cIMPACT‐4 consensus proposed pediatric low‐grade gliomas of the diffuse type to be characterized by distinct molecular changes rather than distinct histological features (2). Very recently, Fukuoka et al described a small series of pediatric oligodendroglioma‐like tumors with BRAF V600E mutations (3). Interestingly, they exhibited molecular changes usually associated with adult high‐grade gliomas: chromosome instability, chromosome 7 gains and chromosome 10 loss, but had an indolent natural history.

We have collected four more cases which we believe have great similarity to Fukuoka et al’s cases.

儿科低级别胶质瘤的特征在于一系列不同的分子畸变。最近的 cIMPACT-4 共识提出弥漫型小儿低级别胶质瘤的特征在于不同的分子变化而不是不同的组织学特征 ( 2 )。最近，Fukuoka等人描述了一系列具有 BRAF V600E 突变的小儿少突胶质细胞瘤样肿瘤 ( 3 )。有趣的是，他们表现出通常与成人高级别胶质瘤相关的分子变化：染色体不稳定、7 号染色体获得和 10 号染色体丢失，但具有惰性的自然病程。

我们收集了另外四个我们认为与 Fukuoka等人的案例非常相似的案例。