Bipolar Disorder (BD) is associated with a decrease in cellular resilience. Despite the half a century old discovery of lithium's efficacy for the treatment of BD, its exact mechanisms remain elusive. Accumulating data suggest that lithium's cytoprotective properties involve the modulation of several UPR proteins, such as GRP78. Mesencephalic astrocyte‐derived neurotrophic factor (MANF) is an endoplasmic reticulum resident protein that regulates proteostasis through directly interacting with GRP78. The purpose of this study was to determine whether lithium increases MANF expression using cellular and rodent models and, if so, to elucidate the cellular mechanisms of action.

中文翻译：

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情绪稳定剂锂的新作用机理

双相情感障碍（BD）与细胞弹性下降有关。尽管有半个世纪的历史发现锂具有治疗BD的功效，但其确切的机理仍然难以捉摸。越来越多的数据表明，锂的细胞保护特性涉及几种UPR蛋白（例如GRP78）的调节。中脑星形胶质细胞源性神经营养因子（MANF）是一种内质网驻留蛋白，可通过与GRP78直接相互作用来调节蛋白稳态。这项研究的目的是使用细胞模型和啮齿动物模型确定锂是否增加MANF表达，如果是，则阐明细胞的作用机理。