The Stetter reaction is actually a special C−C bond forming reaction through a 1,4‐addition reaction in the presence of nucleophilic catalyst. It involves a reaction between aldehydes and Michael acceptors catalyzed by N‐heterocyclic carbenes (NHC's) leading to preparation of 1,4‐dicarbonyl compounds via carbon‐carbon bond formation. It offers a powerful approach to access 1,4‐dicarbonyl compounds which are significant starting materials and intermediates in the synthesis of several heterocyclic systems, and bioactive heterocyclic framework which are present in natural products. In this review we try to underscore the recent advances in Stetter reaction and its applications from 2015 till date. Notably, we focused on the applications of Stetter reaction in the synthesis of various heterocyclic systems and total synthesis of natural products, which have largely been overlooked, previously.

中文翻译：

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斯特特反应及相关化学的最新进展：最新进展

Stetter反应实际上是在亲核催化剂存在下通过1,4加成反应形成的特殊C-C键形成反应。它涉及N杂环卡宾（NHC's）催化的醛与Michael受体之间的反应，从而导致通过1,4-二羰基化合物的制备碳-碳键的形成。它提供了一种强大的方法来获取1,4-二羰基化合物，这些化合物是几种杂环系统合成中的重要起始原料和中间体，以及天然产物中存在的生物活性杂环骨架。在这篇综述中，我们试图强调从2015年至今Stetter反应及其应用的最新进展。值得注意的是，我们专注于Stetter反应在各种杂环系统的合成和天然产物的全合成中的应用，而这些在以前已经被广泛忽视。