High solids content complicates in situ analysis of chemical processing, biological suspensions, and environmental streams. In most cases, analytical methods require at least one pre‐treatment step of a small volume of sample before a particle‐free fluid can be analyzed. We have developed a continuous in situ sampler that can “sip” particle‐free solution from a turbulent high solids content stream (a slurry). An open microfluidic chip with an extended slit opening shields the internal laminar flow from the turbulence outside. Unlike other open chips, our chip does not require close proximity to a solid surface and operates in turbulent environments for hours without maintenance. Two applications are demonstrated: monitoring Fe^III in a stirred slurry of mixed ore particles at high solids loading (4 %wt) and paracetamol tablet dissolution profiles for two different formulations.

中文翻译：

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一种开放式微流控芯片，用于从湍流颗粒悬浮液中连续采样溶质

高固体含量使化学处理，生物悬浮液和环境物流的原位分析复杂化。在大多数情况下，分析方法需要至少一小步样品的预处理步骤，然后才能分析无颗粒的流体。我们开发了一种连续的原位采样器，可以从湍流的高固体含量流（浆液）中“吸入”无颗粒的溶液。具有延伸的狭缝开口的开放式微流体芯片可将内部层流与外部湍流隔离开。与其他开放式芯片不同，我们的芯片不需要紧贴固体表面，并且可以在动荡的环境中运行数小时而无需维护。演示了两种应用：监控Fe ^III 在两种不同配方的高固体含量（4％wt）的混合矿石颗粒的搅拌浆液中，对乙酰氨基酚片剂的溶出度曲线。