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Impact of motor and nonmotor symptoms in Parkinson disease for the quality of life: The Japanese Quality-of-Life Survey of Parkinson Disease (JAQPAD) study
Journal of the Neurological Sciences ( IF 4.4 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.jns.2020.117172
Kanako Kurihara , Ryoko Nakagawa , Miwako Ishido , Yoko Yoshinaga , Jun Watanabe , Yuka Hayashi , Takayasu Mishima , Shinsuke Fujioka , Yoshio Tsuboi

INTRODUCTION Parkinson's disease (PD) is characterized by a range of classic motor symptoms and heterogeneous nonmotor symptoms that affect patients' quality of life (QoL). Studies have individually reported the effect of either motor or nonmotor symptoms on patients' QoL; however, a thorough assessment of the symptoms that have the greatest influence on QoL is limited. This JAQPAD study examined the effect of both motor and nonmotor symptoms and patient demographics on QoL in a large population of patients with PD in Japan. METHODS All members of the Japan Parkinson's Disease Association were invited to participate in the study. Questionnaires assessing wearing-off symptoms (the 9-item Wearing-Off Questionnaire [WOQ-9]), nonmotor symptoms (Non-Motor Symptoms Questionnaire [NMSQ]) and QoL (the 8-item Parkinson's Disease Questionnaire [PDQ-8]) were included. Multiple regression analyses assessed the effect of clinical factors on the PDQ-8 Summary Index (PDQ-8 SI). Spearman rank correlation coefficient (r) estimated the correlation between each subdomain score of nine NMSQ domains and the PDQ-8 SI. RESULTS A total of 3022 patients were included in the analysis. The PDQ-8 SI score correlated with off-time, age, duration of PD, work status, and the NMSQ total score and subdomain scores. Memory problems correlated most strongly with the PDQ-8 SI score (r = 0.4419), followed by mood (r = 0.4387) and digestive problems (r = 0.4341; p < 0.0001). CONCLUSIONS Physicians tend to focus on motor symptoms, while nonmotor symptoms often go under-recognized in clinical practice. This JAQPAD study highlights the importance of recognition and management of both motor and nonmotor symptoms, which together significantly affect patient QoL.

中文翻译:

帕金森病运动和非运动症状对生活质量的影响:日本帕金森病生活质量调查 (JAQPAD) 研究

引言 帕金森病 (PD) 的特征是一系列典型的运动症状和影响患者生活质量 (QoL) 的异质非运动症状。研究单独报告了运动或非运动症状对患者 QoL 的影响;然而,对 QoL 影响最大的症状的彻底评估是有限的。这项 JAQPAD 研究检查了运动和非运动症状以及患者人口统计学对日本大量 PD 患者生活质量的影响。方法 日本帕金森病协会的所有成员都被邀请参加这项研究。评估磨损症状的问卷(9 项磨损问卷 [WOQ-9])、非运动症状(非运动症状问卷 [NMSQ])和 QoL(8 项帕金森氏症)s 疾病问卷 [PDQ-8]) 被包括在内。多元回归分析评估了临床因素对 PDQ-8 总结指数 (PDQ-8 SI) 的影响。Spearman 等级相关系数 (r) 估计了 9 个 NMSQ 域的每个子域得分与 PDQ-8 SI 之间的相关性。结果 共有 3022 名患者被纳入分析。PDQ-8 SI 分数与休息​​时间、年龄、PD 持续时间、工作状态以及 NMSQ 总分和子域分数相关。记忆问题与 PDQ-8 SI 分数相关性最强 (r = 0.4419),其次是情绪 (r = 0.4387) 和消化问题 (r = 0.4341;p < 0.0001)。结论 医生倾向于关注运动症状,而非运动症状在临床实践中经常被忽视。
更新日期:2020-12-01
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