Abstract The purpose of this study was to characterise the metabolome of bovine colostrum and milk in the initial days of lactation. Colostrum and milk samples were collected from 18 cows representing an even spread of 1st, 2nd and 3rd lactation (n = 6) over the first 6 days of lactation. Samples were subsequently analysed using 1H-NMR. The metabolome of defatted colostrum and milk in the days immediately post parturition was demonstrated to be complex and changed significantly over time. The colostrum was rich in nutrients beneficial for growth and development of the new-born mammal with significantly higher levels of essential branched chain amino acids and choline and orotic acid that decreased in the subsequent days as milk composition evolved to that of regular milk. Multivariate analysis of metabolome profiles using PLSDA was demonstrated to clearly distinguish between colostrum and subsequent milk samples.

中文翻译：

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1H-NMR 测定泌乳开始时的牛初乳和牛奶代谢组

摘要 本研究的目的是表征泌乳初期牛初乳和牛奶的代谢组学。从 18 头奶牛收集初乳和牛奶样品，代表第 1、第 2 和第 3 次泌乳（n = 6）在泌乳的前 6 天均匀分布。随后使用1H-NMR分析样品。分娩后几天的脱脂初乳和牛奶的代谢组被证明是复杂的，并且随着时间的推移发生显着变化。初乳富含对新生哺乳动物生长和发育有益的营养物质，必需支链氨基酸、胆碱和乳清酸的含量显着升高，随着牛奶成分演变为普通牛奶的成分，这些营养成分在随后的几天内下降。