Antibodies, T cell receptors and major histocompatibility complex molecules are members of the immunoglobulin superfamily and have pivotal roles in the immune system. The fine interrelation between them regulates several immune functions. Here, we describe lesser-known functions ascribed to these molecules in generating and maintaining immune response. Particularly, we outline the contribution of antibody- and T cell receptor-derived complementarity-determining region neoantigens, antigenized antibodies, as well as major histocompatibility complex class I molecules-derived epitopes to the induction of protective/therapeutic immune responses against pathogens and cancer. We discuss findings of our own and other studies describing protective mechanisms, based on immunogenic properties of immunoglobulin superfamily members, and evaluate the perspectives of application of this class of immunogens in molecular vaccines design.

抗体，T细胞受体和主要的组织相容性复合物分子是免疫球蛋白超家族的成员，在免疫系统中起关键作用。它们之间的良好关系调节了几种免疫功能。在这里，我们描述了归因于这些分子在生成和维持免疫反应中鲜为人知的功能。特别是，我们概述了抗体和T细胞受体衍生的互补决定区新抗原，抗原化的抗体以及主要组织相容性复合物I类分子的抗原决定簇对诱导针对病原体和癌症的保护性/治疗性免疫反应的贡献。我们将根据免疫球蛋白超家族成员的免疫原性讨论我们自己的研究和其他描述保护机制的研究结果，