Drug delivery systems for the sustained and target delivery of doxorubicin to tumor cells are a topic of interest due to the efficacy of the doxorubicin in cancer treatment. The use of polymers such as Pluronic is being studied widely for the formulation of doxorubicin hydrochloride. However, the basic understanding of the physicochemical properties of pluronic micelles in presence of doxorubicin hydrochloride is a very essential topic of study. Doxorubicin hydrochloride is fluorescent; this helped us to study its sensitivity towards the Pluronic microenvironment using the fluorescence technique. In this work, the interaction and place of location of doxorubicin hydrochloride in Pluronic F127 and P123 micelles has been studied extensively using steady-state fluorescence intensity, dynamic fluorescence lifetime, quenching studies, dynamic light scattering, and zeta potential measurements, at different Pluronic concentrations. Using a fluorescence quenching experiment, doxorubicin hydrochloride was found to reside near the hydrophilic PEO corona region of the Pluronic micelles. For both the Pluronic, in the concentration range of study, the micellar size was found to be below 30 nm; this may have a greater advantage for various applications.

由于多柔比星在癌症治疗中的功效，用于将多柔比星持续和靶向输送至肿瘤细胞的药物输送系统是一个令人感兴趣的话题。正在广泛研究使用聚合物如 Pluronic 来配制盐酸多柔比星。然而，在盐酸多柔比星存在下对普朗尼克胶束的物理化学性质的基本了解是一个非常重要的研究课题。盐酸多柔比星有荧光；这有助于我们使用荧光技术研究其对 Pluronic 微环境的敏感性。在这项工作中，使用稳态荧光强度、动态荧光寿命、淬灭研究、在不同的 Pluronic 浓度下进行动态光散射和 zeta 电位测量。使用荧光猝灭实验，发现盐酸多柔比星位于 Pluronic 胶束的亲水性 PEO 电晕区域附近。对于 Pluronic，在研究的浓度范围内，发现胶束尺寸低于 30 nm；这对于各种应用可能具有更大的优势。