Abstract

In the present study, a functional annotation of genes predisposing to schizophrenia and celiac disease was carried out using Cytoscape version 3.7.1. The identified genes are involved (even jointly) in the regulation of the development and functioning of nerve cells and activation of the immune response. Common genes for both diseases (NOTCH4 and HLA-DQA1) are hereditary factors in the development of schizophrenia and celiac disease. According to the results of functional annotation, genes susceptible to schizophrenia and celiac disease were annotated by terms from Gene Ontology; the number of common groups of functions was 44. The results suggest that molecular mechanisms responsible for the differentiation and proliferation of cells of both the immune system and the nervous system are involved in the comorbid development of schizophrenia and celiac disease. It was found that a significant number (up to 179) of genes could be involved in the implementation of a single biological process. However, in some cases, the same gene could be represented in several related processes.

中文翻译：

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精神分裂症和腹腔疾病易感基因的功能注释

摘要

在本研究中，使用Cytoscape版本3.7.1对易患精神分裂症和乳糜泻的基因进行了功能注释。鉴定出的基因参与（甚至共同参与）神经细胞发育和功能的调节以及免疫反应的激活。两种疾病的共同基因（NOTCH4和HLA-DQA1）是精神分裂症和腹腔疾病发展的遗传因素。根据功能注释的结果，易感性精神分裂症和乳糜泻的基因通过基因本体论的术语进行注释；共有的一组功能为44个。结果表明，负责免疫系统和神经系统细胞分化和增殖的分子机制与精神分裂症和乳糜泻的合并发展有关。已经发现，单个生物过程的实施中可能涉及大量（多达179个）基因。但是，在某些情况下，相同的基因可以在多个相关过程中表达。