This study demonstrated the availability of an anion-exchange spin column method for the isolation of astatine-211 (211At) from bismuth (Bi). 211At was isolated in medium-to-excellent recovery efficiencies when loading 211At with 8M HCl (75.3–79.1%), and 8M HNO3 (35.9–54.3%). The processing time of the optimized protocol was about 40 minutes. A neutralized eluent afforded an 211At-labeled phenylalanine derivative even in the absence of oxidant (radiochemical yield: 75.4%). These results indicate the anion-exchange spin column is useful for the isolation of 211At and the following synthesis of astatinated compounds, which is the first to isolate 211At with an anion-exchange method.

中文翻译：

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使用阴离子交换自旋柱方法简单分离 211At

本研究证明了阴离子交换自旋柱方法可用于从铋 (Bi) 中分离砹 211 (211At)。当用 8M HCl (75.3–79.1%) 和 8M HNO3 (35.9–54.3%) 加载 211At 时，211At 以中等至优异的回收效率分离。优化方案的处理时间约为 40 分钟。即使在没有氧化剂的情况下，中和的洗脱液也能提供 211 At 标记的苯丙氨酸衍生物（放射化学产率：75.4%）。这些结果表明阴离子交换离心柱可用于分离 211At 和后续合成砹化合物，这是第一个用阴离子交换方法分离 211At。