Dental stem cells (DSCs) are self-renewable cells that can be obtained easily from dental tissues, and are a desirable source of autologous stem cells. The use of DSCs for stem cell transplantation therapeutic approaches is attractive due to their simple isolation, high plasticity, immunomodulatory properties, and multipotential abilities. Using appropriate scaffolds loaded with favorable biomolecules, such as growth factors, and cytokines, can improve the proliferation, differentiation, migration, and functional capacity of DSCs and can optimize the cellular morphology to build tissue constructs for specific purposes. An enormous variety of scaffolds have been used for tissue engineering with DSCs. Of these, the scaffolds that particularly mimic tissue-specific micromilieu and loaded with biomolecules favorably regulate angiogenesis, cell-matrix interactions, degradation of extracellular matrix, organized matrix formation, and the mineralization abilities of DSCs in both in vitro and in vivo conditions. DSCs represent a promising cell source for tissue engineering, especially for tooth, bone, and neural tissue restoration. The purpose of the present review is to summarize the current developments in the major scaffolding approaches as crucial guidelines for tissue engineering using DSCs and compare their effects in tissue and organ regeneration.

中文翻译：

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牙科干细胞：生物材料和支架在开发新型治疗策略中的作用。

牙科干细胞（DSC）是可以从牙齿组织容易获得的可自我更新的细胞，并且是自体干细胞的理想来源。由于其简单的分离，高可塑性，免疫调节特性和多潜能，将DSC用于干细胞移植治疗方法具有吸引力。使用装有有利的生物分子（例如生长因子和细胞因子）的合适支架，可以改善DSC的增殖，分化，迁移和功能能力，并且可以优化细胞形态以构建用于特定目的的组织构建体。大量的支架已经被用于DSC的组织工程。在这些支架中，特别是模仿组织特异的微环境并负载有生物分子的支架可有利地调节血管生成，体外和体内条件。DSC代表了组织工程特别是牙齿，骨骼和神经组织修复的有希望的细胞来源。本综述的目的是总结主要脚手架方法的最新进展，作为使用DSC进行组织工程的重要指导方针，并比较它们在组织和器官再生中的作用。